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KMID : 0360419820180010011
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Korean Journal of Pharmacology
1982 Volume.18 No. 1 p.11 ~ p.16
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Effect of Prostaglandin F_(2α) on the Central Regulation of Cardiovascular Effect in Conscious Rat
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Abstract
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This study was carried out in order to clarify whether the cardiovascular effect of prostaglandin(PG) F2, might be centrally mediated. In unrestrained conscious rat, PGF2 was administered into the lateral ventricle. The mechanism of action was also studied by observing the interaction with several adrenergic antagonists injected subcutaneously. Indomethacin was administered into lateral ventricle to investigate the role of encogenous PG F2, on the central regulation of cardiovascular system.
The results were as follows:
1) The intraventricular injection of PGF2,, produced an increase in blood pressure and heart rate.
2) The pretreatment with phenoxybenzamine(2 mg/kg, s.c.) inhibited pressor, but not
heart rate responses to the intraventricular injection of PGF2,,(2 pg/kg).
3) The pretreatment with propranolol (1 mg/kg, s.c.) inhibited tachycardia, but not pressor
responses to the intraventricular injection of PGF2,,(2 pg/kg).
4) The intraventricular injection of indomethacin(40 pg/kg) could not induce significant
changes in blood pressure and heart rate.
5) The result indicates that intraventricular injection of PGF2,, produces pressor and tachycardia responses in the unanesthetized rat, and it is mediated primarily by centrally increased sympathetic outflow. But the endogenous PGF2,, synthetized in the brain seems to play a minor role in the direct regulation of cardiovascular system.
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